Puffiness and fluid retention in the hands and feet, joint aches, wrist tingling (carpal tunnel), and blood sugar creeping up over weeks — most pronounced with MK-677 and somatropin.
These accumulate rather than strike suddenly — reassess and stop rather than pushing the dose up. Check glucose if you can.
A severe persistent headache with vision changes (possible raised intracranial pressure), or symptoms of very high blood sugar — extreme thirst, confusion, vomiting — warrant urgent care.
Allergic reaction: hives, swelling of the lips, tongue or throat, wheezing or dizziness can escalate to anaphylaxis within minutes — call 911 immediately. Site infection: spreading redness, heat, swelling, pus or fever is not wait-and-see; an abscess or cellulitis can need drainage or IV antibiotics. Unverified product: grey-market vials are frequently mislabelled or contaminated, so a reaction may be to endotoxin or the wrong contents, not the named compound.
A synthetic fragment corresponding to the C-terminal region of human growth hormone, originally advanced on the hypothesis that GH's lipolytic activity could be separated from its growth-promoting and glucose-perturbing activity. It does not raise IGF-1 and lacks GH receptor-mediated growth activity. The proposed lipolytic mechanism has not been firmly established.
This one has a clear answer, and it is negative. AOD-9604 progressed to Phase 2b trials in obesity and failed to separate from placebo on weight endpoints. It is one of the few peptides in this library with a definitive human efficacy result — and the result was no benefit.
Not FDA-approved. FDA has previously rejected attempts to market it as a dietary supplement, taking the position that it is a drug. Prohibited in sport (WADA S2).
Trial safety was relatively unremarkable — but a favourable safety profile in a drug that does not work is not a reason to use it.
Phase 2b obesity trial: 1 mg once daily, oral — a dose that failed to beat placebo. It is reported here as a study dose that did not work, not a recommendation.
Reported from clinical trials or FDA labelling as a matter of record. It is not a recommendation, and for unapproved compounds no dose has been shown safe or effective in humans.
Above is what was administered in trials or on FDA labels, reported as fact. We do not convert it into a personal protocol, calculate a dose for your body weight, or tell you what to inject or how to reconstitute it — that decision belongs with a licensed physician. See our editorial policy.
Regulatory status changes. This page reflects our reading of public sources as of July 2026 and should be independently verified before it is relied upon.