A 24-amino-acid peptide encoded within the mitochondrial 16S rRNA gene, identified through screens for cytoprotective factors in Alzheimer's disease models. It signals through a trimeric cell-surface receptor complex and also binds IGFBP-3, with reported anti-apoptotic effects. Circulating levels decline with age.
Preclinical work reports neuroprotective and cytoprotective effects in cellular and rodent models. Human data are observational — associations between levels and ageing or disease — not interventional. No trials establish benefit from administration.
Not FDA-approved.
No meaningful human safety data. Anti-apoptotic activity warrants theoretical oncological caution.
Forge Bioenergy does not publish dosing, reconstitution, or administration protocols for any peptide. See our editorial policy for why. If you are considering any substance on this page, that conversation belongs with a licensed physician.
Regulatory status changes. This page reflects our reading of public sources as of July 2026 and should be independently verified before it is relied upon.