Puffiness and fluid retention in the hands and feet, joint aches, wrist tingling (carpal tunnel), and blood sugar creeping up over weeks — most pronounced with MK-677 and somatropin.
These accumulate rather than strike suddenly — reassess and stop rather than pushing the dose up. Check glucose if you can.
A severe persistent headache with vision changes (possible raised intracranial pressure), or symptoms of very high blood sugar — extreme thirst, confusion, vomiting — warrant urgent care.
Allergic reaction: hives, swelling of the lips, tongue or throat, wheezing or dizziness can escalate to anaphylaxis within minutes — call 911 immediately. Site infection: spreading redness, heat, swelling, pus or fever is not wait-and-see; an abscess or cellulitis can need drainage or IV antibiotics. Unverified product: grey-market vials are frequently mislabelled or contaminated, so a reaction may be to endotoxin or the wrong contents, not the named compound.
A pentapeptide agonist at the ghrelin receptor, GHS-R1a, on pituitary somatotrophs and the hypothalamus. Notable for selectivity: unlike earlier GHRPs, it releases GH with minimal effect on ACTH, cortisol, or prolactin at comparable doses. Acts through a pathway separate from GHRH, which is why the two classes are often studied together.
Preclinical characterisation is reasonably good. Early human work was conducted by the original developer but development was discontinued. No controlled trials establish clinical benefit for any indication.
Not FDA-approved. No approved product anywhere. Was subject to FDA 503A bulk substance review. Prohibited in sport (WADA S2).
Human safety data are limited to small early-phase studies. Ghrelin-receptor agonism affects appetite and glucose handling. Long-term consequences are unknown.
No established human dose. Early-phase work by the original developer was discontinued; no regimen was ever validated against a clinical outcome.
Reported from clinical trials or FDA labelling as a matter of record. It is not a recommendation, and for unapproved compounds no dose has been shown safe or effective in humans.
Above is what was administered in trials or on FDA labels, reported as fact. We do not convert it into a personal protocol, calculate a dose for your body weight, or tell you what to inject or how to reconstitute it — that decision belongs with a licensed physician. See our editorial policy.
Regulatory status changes. This page reflects our reading of public sources as of July 2026 and should be independently verified before it is relied upon.